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Symbol
Name
ID

Nfix
nuclear factor I/X
MGI:97311

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Drooling

Optic nerve hypoplasia

Hydrocephalus

Ventriculomegaly

Pachygyria

Agenesis of corpus callosum

Hypoplasia of the corpus callosum

Absent septum pellucidum

Cerebral atrophy

Cerebellar hypoplasia

Cervical cord compression

Delayed speech and language development

Anxiety

Autistic behavior

Intellectual disability

Intellectual disability, moderate

Obstructive sleep apnea

Brisk reflexes

Global developmental delay

Motor delay

Delayed ability to walk

Disease(s) Associated with NFIX

Marshall-Smith syndrome

Sotos syndrome 2

Mouse Phenotypes

abnormal brain morphology

abnormal cortical plate morphology

hydrocephaly

increased brain weight

increased brain size

enlarged lateral ventricles

dilated lateral ventricle

dilated third ventricle

abnormal brain commissure morphology

abnormal corpus callosum morphology

abnormal hippocampal commissure morphology

abnormal anterior commissure morphology

abnormal retrosplenial region morphology

increased cingulate cortex size

abnormal hippocampus morphology

abnormal hippocampus CA1 region morphology

abnormal dentate gyrus morphology

abnormal cerebral cortex morphology

abnormal neocortex morphology

increased neocortex size

abnormal somatosensory cortex morphology

Availability

Mouse Genotype

Nfix^tm1.1Rmg/Nfix^tm1.1Rmg

Nfix^tm1Aes/Nfix^tm1Aes

Nfix^tm1.1Rmg/Nfix⁺

Nfix^tm1Aes/Nfix⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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